Exploring Modular Protein Architecture

Aims

Over the last few years a new paradigm has been emerging concerning the nature of Eukaryotic regulatory proteins - contrasting with the nice neat globular protein view expounded by biochemical and cell biological textbooks.
Instead, many proteins have a remarkable number of architecture modules - including long natively disordered segments and short linear motifs that are awkward to investigate computationally and experimentally.

The course will set the scene by introducing the biological concepts behind these architecture modules and provide extensive hands-on application of the relevant bioinformatics tools with appropriate example proteins.
The power - but also the limitations, which remain substantial - of the currently available software will be examined.


Topics

Searching and Mining Biological Databases

Predicting Protein Modules
- Globular Domains
- Native Disorder
- Linear Motifs
Multiple Sequence Alignment

Structures of Protein-Protein Interactions

Protein-Protein Interaction Networks


Programme

Wednesday, 3rd December
Introduction to Modular Protein Architecture
Keyword Searching of Biological Databases Sequence
Similarity Searches of Biological Databases

Thursday, 4th December
Predicting Globular Domains and Native Disorder
Multiple Sequence Alignment
Identifying Potential ELMs Web Services

Friday, 5th December
Structure of Protein-Protein Interactions
Protein-Protein Interaction Networks
Student Presentations